Hydrochloric Acid → HCID 67179989, compound

HRID 2403883Notes

Reaction equation

HRID 2403883 reaction equation
[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:24]C)[N:12]2[CH2:15][CH:16]2[CH2:21][CH2:20][CH2:19][N:18]([CH2:22][CH3:23])[CH2:17]2)=[C:8]([NH2:26])[N:7]=1)[CH2:2][CH2:3][CH3:4].Cl>CO.O1CCOCC1>[NH2:26][C:8]1[N:7]=[C:6]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])[N:14]=[C:13]2[C:9]=1[NH:10][C:11](=[O:24])[N:12]2[CH2:15][CH:16]1[CH2:21][CH2:20][CH2:19][N:18]([CH2:22][CH3:23])[CH2:17]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 58306206HCID 58306206, compound

Product 1

HCID 67179989HCID 67179989, compoundYield 85.1%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

2-Butoxy-9-[(1-ethyl-3-piperidinyl)methyl]-8-methoxy-9H-purin-6-amine (99 mg) was dissolved in methanol (2 ml) and 4N hydrogen chloride in dioxan (1 ml) added. After 5 hours the reaction mixture was stripped, quenched with water then saturated sodium hydrogen carbonate added, when a solid precipitated. This was filtered, washed with water and dried to yield 81 mg of the title compound as a white solid.

Workup

  1. customquenched with water
  2. additionsaturated sodium hydrogen carbonate added
  3. customwhen a solid precipitated
  4. filtrationThis was filtered
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-a64ee857b5844c938e97267c0e9270f1
Source dataset
uspto-grants-2014_08
Patent number
US08802684B2

Reaction notes

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