Hydrochloric Acid → 2-(Butyloxy)-9-(4-piperidinylmethyl)-9H-purin-6-amine hydrochloride

HRID 2403885Notes

Reaction equation

HRID 2403885 reaction equation
[ClH:1].[NH2:2][C:3]1[N:11]=[C:10]([O:12][CH2:13][CH2:14][CH2:15][CH3:16])[N:9]=[C:8]2[C:4]=1[N:5]=[C:6](OC)[N:7]2[CH2:17][CH:18]1[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]1>O1CCOCC1.CO>[ClH:1].[CH2:13]([O:12][C:10]1[N:9]=[C:8]2[C:4]([N:5]=[CH:6][N:7]2[CH2:17][CH:18]2[CH2:19][CH2:20][NH:21][CH2:22][CH2:23]2)=[C:3]([NH2:2])[N:11]=1)[CH2:14][CH2:15][CH3:16]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 583060912-Butoxy-9-(1-tert-butoxycarbonylpiperidin-4-ylmethyl)-8-methoxyadenine

Product 1

HCID 671801992-(Butyloxy)-9-(4-piperidinylmethyl)-9H-purin-6-amine hydrochloride

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

4N hydrogen chloride in dioxane (5.3 mL) was added to a solution of 1,1-dimethylethyl 4-{[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]methyl}-1-piperidinecarboxylate (630 mg) in methanol (16 mL). After 4.5 hours at room temperature, the reaction mixture was concentrated and dried under high vacuum.

Workup

  1. concentrationthe reaction mixture was concentrated
  2. customdried under high vacuum

Sources & evidence

ORD record
ord-189f9d278e9b46b990f589dedf9ee6ad
Source dataset
uspto-grants-2014_08
Patent number
US08802684B2

Reaction notes

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