Hydrochloric Acid → HCID 67233800, compound

HRID 2403903Notes

Reaction equation

HRID 2403903 reaction equation
[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:27]C)[N:12]2[CH2:15][CH:16]2[CH2:21][CH2:20][CH2:19][N:18]([CH:22]3[CH2:26][CH2:25][CH2:24][CH2:23]3)[CH2:17]2)=[C:8]([NH2:29])[N:7]=1)[CH2:2][CH2:3][CH3:4].[ClH:30]>CO.O1CCOCC1>[ClH:30].[NH2:29][C:8]1[N:7]=[C:6]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])[N:14]=[C:13]2[C:9]=1[NH:10][C:11](=[O:27])[N:12]2[CH2:15][CH:16]1[CH2:21][CH2:20][CH2:19][N:18]([CH:22]2[CH2:23][CH2:24][CH2:25][CH2:26]2)[CH2:17]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 58306205HCID 58306205, compound

Product 1

HCID 67233800HCID 67233800, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of 2-(butyloxy)-9-[(1-cyclopentyl-3-piperidinyl)methyl]-8-(methyloxy)-9H-purin-6-amine (37.2 mg, 0.092 mmol) in methanol (3 ml) at room temperature was added 4.0 M HCl in 1,4-dioxane (0.578 ml). The reaction mixture was stirred at ambient temperature overnight. The reaction solution was evaporated under N2 in a Radleys blow down unit to give the title compound as an off-white solid (39 mg).

Workup

  1. customThe reaction solution was evaporated under N2 in a Radleys blow down unit

Sources & evidence

ORD record
ord-1480550ae9db4c1fa372f5e3dd46ea32
Source dataset
uspto-grants-2014_08
Patent number
US08802684B2

Reaction notes

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