Hydrochloric Acid → [2,4'-Bipyridine]-3-carboxylic acid dihydrochloride

HRID 240393Notes

Reaction equation

HRID 240393 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]([O:9]CC)=[O:8])[C:2]=1[C:12]1[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=1.[ClH:18]>>[ClH:18].[ClH:18].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]([OH:9])=[O:8])[C:2]=1[C:12]1[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 46317743Ethyl [2,4'-bipyridine]-3-carboxylate

Product 1

HCID 84819756[2,4'-Bipyridine]-3-carboxylic acid dihydrochloride

Procedure

A solution of ethyl 2,4′-bipyridine-3-carboxylate (14.1 g) in 6 N hydrochloric acid (200 mL) was heated under reflux overnight. The solvent was evaporated under reduced pressure, to the obtained residue was added toluene, and the solvent was again evaporated under reduced pressure to give the title compound (16.4 g).

Workup

  1. temperatureunder reflux overnight
  2. customThe solvent was evaporated under reduced pressure, to the obtained residue
  3. additionwas added toluene
  4. customthe solvent was again evaporated under reduced pressure

Sources & evidence

ORD record
ord-0985a229539f494894619095dc9732a6
Source dataset
uspto-grants-2014_02
Patent number
US08648079B2

Reaction notes

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