Hydrochloric Acid → 2-(Pyrimidin-4-yl)nicotinic acid dihydrochloride

HRID 240395Notes

Reaction equation

HRID 240395 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[N:16]=[CH:15][CH:14]=[CH:13][C:8]=2[C:9]([O:11]C)=[O:10])=[N:3][CH:2]=1.[ClH:17]>C(O)(=O)C>[ClH:17].[ClH:17].[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[N:16]=[CH:15][CH:14]=[CH:13][C:8]=2[C:9]([OH:11])=[O:10])=[N:3][CH:2]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86680858Methyl 2-(pyrimidin-4-yl)nicotinate

Product 1

HCID 866808562-(Pyrimidin-4-yl)nicotinic acid dihydrochloride

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of methyl 2-(pyrimidin-4-yl)nicotinate (0.19 g), acetic acid (1.0 mL) and 6 N hydrochloric acid (5 mL) was heated under reflux for 5 hr. The solvent was evaporated under reduced pressure to give the title compound (0.26 g).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 5 hr
  3. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-b824635fb4ec44e19f1d313ed721598b
Source dataset
uspto-grants-2014_02
Patent number
US08648079B2

Reaction notes

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