Lithium Hydroxide → 2-(3-Methyl-1,2,4-oxadiazol-5-yl)isonicotinic acid

HRID 2404291Notes

Reaction equation

HRID 2404291 reaction equation
[OH-].[Li+].[CH3:3][C:4]1[N:8]=[C:7]([C:9]2[CH:10]=[C:11]([CH:16]=[CH:17][N:18]=2)[C:12]([O:14]C)=[O:13])[O:6][N:5]=1>C(O)C>[CH3:3][C:4]1[N:8]=[C:7]([C:9]2[CH:10]=[C:11]([CH:16]=[CH:17][N:18]=2)[C:12]([OH:14])=[O:13])[O:6][N:5]=1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 67151212Methyl 2-(3-methyl-1,2,4-oxadiazol-5-yl)isonicotinate

Product 1

HCID 582525372-(3-Methyl-1,2,4-oxadiazol-5-yl)isonicotinic acidYield 89%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of lithium hydroxide (15 g, 0.35 mol), ethanol (500 mL) and methyl 2-(3-methyl-1,2,4-oxadiazol-5-yl)isonicotinate (52 g, 0.23 mol) were stirred at room temperature for 5 hours, then mixture was concentrated in vacuo. Water was added then extracted with ethyl acetate. The water layer was brought to pH 1.5 with aqueous 1N hydrochloric acid and extracted with ethyl acetate. The organic layer was concentrated in vacuo to afford the title compound as a white solid (42 g). 1H NMR (300 MHz, DMSO-d6) δ ppm 14.08 (br s, 1H) 9.00-8.98 (m, 1H) 8.50 (s, 1H) 8.09-8.07 (m, 1H), 2.46 (s, 3H).

Workup

  1. concentrationmixture was concentrated in vacuo
  2. additionWater was added
  3. extractionthen extracted with ethyl acetate
  4. extractionextracted with ethyl acetate
  5. concentrationThe organic layer was concentrated in vacuo

Sources & evidence

ORD record
ord-fa425f15311a469bbaf07b5362c8b90d
Source dataset
uspto-grants-2014_08
Patent number
US08802690B2

Reaction notes

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