Sarcosine t-butyl ester hydrochloride → HCID 66678536, compound

HRID 2404324Notes

Reaction equation

HRID 2404324 reaction equation
[C:1]([C:3]1[CH:10]=[CH:9][C:6]([CH2:7]Br)=[C:5]([O:11][CH3:12])[CH:4]=1)#[N:2].Cl.[C:14]([O:18][C:19](=[O:23])[CH2:20][NH:21][CH3:22])([CH3:17])([CH3:16])[CH3:15]>>[C:1]([C:3]1[CH:10]=[CH:9][C:6]([CH2:7][N:21]([CH3:22])[CH2:20][C:19]([O:18][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:23])=[C:5]([O:11][CH3:12])[CH:4]=1)#[N:2]

Participants

3

Reactant 2

HCID 11252350Sarcosine t-butyl ester hydrochlorideHCID 147529954-(Bromomethyl)-3-methoxybenzonitrile

Product 1

HCID 66678536HCID 66678536, compound

Procedure

The title compound was prepared following the general procedure 10, starting from 4-cyano-2-methoxybenzyl bromide (Carbocore) and sarcosine tert-butyl ester hydrochloride. It was isolated as a colorless oil. 1H NMR (DMSO-d6, 300 MHz) δ 7.53 (d, J=7.7 Hz, 1H), 7.45-7.40 (m, 2H), 3.83 (s, 3H), 3.69 (s, 2H), 3.20 (s, 2H), 2.27 (s, 3H), 1.42 (s, 9H). LC/MS (Method B): 291.0 (M+H)+. HPLC (Method A) Rt 2.52 min (Purity: 93.5%).

Workup

  1. customIt was isolated as a colorless oil

Sources & evidence

ORD record
ord-52fb57aee1654cfc8204446746a134bd
Source dataset
uspto-grants-2014_08
Patent number
US08802704B2

Reaction notes

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