HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 3-Amino-1-phenylcyclopentanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 2-(3-Hydroxy-3-phenylcyclopentyl)isoindoline-1,3-dione | HCID 68313468 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | tert-Butyl methyl ether | HCID 15413 | — |
| Product | 3-Amino-1-phenylcyclopentanol | HCID 68313284 | 55% |
Reaction Steps
A solution of Example 58B (107 mg, 0.348 mmol), MeOH (5.5 mL), and hydrazine monohydrate (0.424 mL, 8.70 mmol) was heated at 50° C. for 1 hour, cooled to ambient temperature, and diluted with MTBE (50 mL) and water (25 mL). The layers were separated. The organic layer was washed with water (10 mL) and brine (10 mL), dried (Na2SO4), and concentrated to provide the title compound (34 mg, 0.19 mmol, 55% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08802711B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-d9587df7c4ad41a893f1a40b825c456b |
| Source note | uspto-grants-2014_08 |