反应详情

A solution of Example 58B (107 mg, 0.348 mmol), MeOH (5.5 mL), and hydrazine monohydrate (0.424 mL, 8.70 mmol) was heated at 50° C. for 1 hour, cooled to ambient temperature, and diluted with MTBE (50 mL) and water (25 mL). The layers were separated. The organic layer was washed with water (10 mL) and brine (10 mL), dried (Na2SO4), and concentrated to provide the title compound (34 mg, 0.19 mmol, 55% yield).

1. customThe layers were separated
2. washThe organic layer was washed with water (10 mL) and brine (10 mL)
3. dry with materialdried (Na2SO4)
4. concentrationconcentrated