Hydrochloric Acid → (cis)-3-(4-Methylthiazol-2-yl)cyclopentanamine hydrochloride

Participants

Reaction Steps

To a solution of Example 120B (100 mg, 0.41 mmol) in ethyl alcohol (3 mL) was added chloroacetone (0.036 mL, 0.45 mmol). The reaction mixture was stirred at reflux overnight, then 2 mL of 2N aqueous HCl was and the mixture was stirred at reflux for 4 h. The mixture was concentrated and the residue triturated in diethyl ether to provide the title compound as a 2:1 cis/trans mixture of diastereomers. MS (ESI+) M/Z 145 [M+H]+.

Provenance & Evidence