反应详情

To a solution of Example 120A (300 mg, 1.3 mmol) in EtOH (2 mL) was added chloroacetone (0.3 mL, 3.9 mmol). The reaction mixture was stirred at reflux for 64 hours, cooled to ambient temperature, and concentrated. Trituration of the residue in diethyl ether afforded the title compound. LC/MS (ESI+) M/Z 167 [M+H]+.

1. temperatureat reflux for 64 hours
2. concentrationconcentrated