Chloroacetone → (cis)-3-(4-Methyloxazol-2-yl)cyclopentanamine hydrochloride

Participants

Reaction Steps

To a solution of Example 120A (300 mg, 1.3 mmol) in EtOH (2 mL) was added chloroacetone (0.3 mL, 3.9 mmol). The reaction mixture was stirred at reflux for 64 hours, cooled to ambient temperature, and concentrated. Trituration of the residue in diethyl ether afforded the title compound. LC/MS (ESI+) M/Z 167 [M+H]+.

Provenance & Evidence