HCID 49963717, compound → HCID 66836093, compound

HRID 2404410Notes

Reaction equation

HRID 2404410 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH:10]([C:12]1[CH:13]=[C:14]([CH3:18])[CH:15]=[CH:16][CH:17]=1)[OH:11]>O1CCOCC1.[Mn]>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]([C:12]1[CH:13]=[C:14]([CH3:18])[CH:15]=[CH:16][CH:17]=1)=[O:11]

Participants

4

Reactant 1

HCID 49963717HCID 49963717, compound

Product 1

HCID 66836093HCID 66836093, compound

Reagents, catalysts & solvents 2

HCID 23930ManganeseCatalystHCID 312751,4-DioxaneSolvent

Procedure

To a solution of (benzothiazol-2-yl)(m-tolyl)methanol (2.41 g) in dioxane (30 mL) is added manganese dioxyde (1.2 molar equivalent). The mixture is stirred overnight at room temperature, then filtered over a clarcel pad. The filtrate is concentrated under reduced pressure. The residue is triturated in heptane and diisopropyl oxyde to give (benzothiazol-2-yl)(m-tolyl)methanone

Workup

  1. filtrationfiltered over a clarcel pad
  2. concentrationThe filtrate is concentrated under reduced pressure
  3. customThe residue is triturated in heptane

Sources & evidence

ORD record
ord-11fafcb8bfd946ee949f052405972343
Source dataset
uspto-grants-2014_08
Patent number
US08802664B2

Reaction notes

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