Potassium Carbonate → HCID 86695322, compound

HRID 2404435Notes

Reaction equation

HRID 2404435 reaction equation
C[Si]([C:5]#[C:6][C:7]1[CH:8]=[C:9]([CH:13]([O:23][CH:24]2[CH2:29][CH2:28][N:27]([CH3:30])[CH2:26][CH2:25]2)[C:14]2[NH:18][C:17]3[CH:19]=[CH:20][CH:21]=[CH:22][C:16]=3[N:15]=2)[CH:10]=[CH:11][CH:12]=1)(C)C.C(=O)([O-])[O-].[K+].[K+]>CO>[C:6]([C:7]1[CH:8]=[C:9]([CH:13]([O:23][CH:24]2[CH2:29][CH2:28][N:27]([CH3:30])[CH2:26][CH2:25]2)[C:14]2[NH:18][C:17]3[CH:19]=[CH:20][CH:21]=[CH:22][C:16]=3[N:15]=2)[CH:10]=[CH:11][CH:12]=1)#[CH:5]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 66835807HCID 66835807, compound

Product 1

HCID 86695322HCID 86695322, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-[(3-trimethylsilylethynylphenyl)(1-methylpiperidin-4-yloxy)-methyl]-1H-benzimidazole (205 mg) in methanol (2 mL) is added potassium carbonate (81 mg). The reaction mixture is stirred at room temperature for 4 hours, then methanol is removed under reduced pressure. The residue is dissolved in water and extracted with ethyl acetate. The organic phase is dried on magnesium sulphate and solvent is removed under reduced pressure to give 2-[(3-ethynylphenyl)(1-methylpiperidin-4-yloxy)methyl]-1H-benzimidazole

Workup

  1. custommethanol is removed under reduced pressure
  2. dissolutionThe residue is dissolved in water
  3. extractionextracted with ethyl acetate
  4. customThe organic phase is dried on magnesium sulphate and solvent
  5. customis removed under reduced pressure

Sources & evidence

ORD record
ord-8b2c4cc6d08642d682d6ff7c5752bfaa
Source dataset
uspto-grants-2014_08
Patent number
US08802664B2

Reaction notes

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