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Methylamine → Tert-butyl 3-hydroxy-4-(methylamino)pyrrolidine-1-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methylamine | HCID 6329 | — |
| 反応物 | tert-Butyl 6-Oxa-3-azabicyclo(3.1.0)hexane-3-carboxylate | HCID 10103880 | — |
| 溶媒 | Diisopropyl Ether | HCID 7914 | — |
| 生成物 | Tert-butyl 3-hydroxy-4-(methylamino)pyrrolidine-1-carboxylate | HCID 21736783 | 96% |
反応手順
Aqueous methylamine solution (40% solution, 812 mL, 3.8 mol) was added to the epoxide 3 (140 g, 0.65 mol) at room temperature and the reaction was stirred until complete. The excess methylamine was removed by distillation under reduced pressure. To the residue obtained, diisopropyl ether (800 mL) was added and the mixture stirred for about 30 min. The solid was filtered, washed with diisopropyl ether (200 mL), then dried to give compound 4 (135 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08802719B2 |
| 出典データセット | uspto-grants-2014_08 |
| ORD ID | ord-c912b3b67c224d90bafc4feab7a4f761 |
| 出典メモ | uspto-grants-2014_08 |