反应详情

Aqueous methylamine solution (40% solution, 812 mL, 3.8 mol) was added to the epoxide 3 (140 g, 0.65 mol) at room temperature and the reaction was stirred until complete. The excess methylamine was removed by distillation under reduced pressure. To the residue obtained, diisopropyl ether (800 mL) was added and the mixture stirred for about 30 min. The solid was filtered, washed with diisopropyl ether (200 mL), then dried to give compound 4 (135 g).

1. customThe excess methylamine was removed by distillation under reduced pressure
2. customTo the residue obtained
3. stirringthe mixture stirred for about 30 min
4. filtrationThe solid was filtered
5. washwashed with diisopropyl ether (200 mL)
6. customdried