5-Methoxycarbonyl-2-methylphenylboronic acid → 3-[5-(2,6-Difluoro-benzoylamino)-thiophen-2-yl]4-methyl-benzoic acid methyl ester

HRID 2404500Notes

Reaction equation

HRID 2404500 reaction equation
[F:1][C:2]1[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[C:3]=1[C:4]([NH:6][C:7]1[S:8][C:9](C2C=CC=C(C(F)(F)F)C=2)=[CH:10][CH:11]=1)=[O:5].[CH3:27][O:28][C:29]([C:31]1[CH:32]=[CH:33][C:34]([CH3:40])=[C:35](B(O)O)[CH:36]=1)=[O:30]>>[CH3:27][O:28][C:29](=[O:30])[C:31]1[CH:32]=[CH:33][C:34]([CH3:40])=[C:35]([C:9]2[S:8][C:7]([NH:6][C:4](=[O:5])[C:3]3[C:2]([F:1])=[CH:25][CH:24]=[CH:23][C:22]=3[F:26])=[CH:11][CH:10]=2)[CH:36]=1

Participants

3

Reactant 2

HCID 121636505-Methoxycarbonyl-2-methylphenylboronic acidHCID 587033772,6-Difluoro-N-[5-(3-trifluoromethyl-phenyl)-thiophen-2-yl]benzamide

Product 1

HCID 587033963-[5-(2,6-Difluoro-benzoylamino)-thiophen-2-yl]4-methyl-benzoic acid methyl ester

Procedure

Compound 118 was synthesized in an analogous fashion as described for Compound 117 except that 5-methoxycarbonyl-2-methylbenzeneboronic acid was used instead of 3-trifluoromethylbenzeneboronic acid in the final step.

Sources & evidence

ORD record
ord-b14776d471d640aebfe57fe6578f2b55
Source dataset
uspto-grants-2014_08
Patent number
US08802721B2

Reaction notes

Loading…