HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Methoxycarbonyl-2-methylphenylboronic acid → 3-[5-(2,6-Difluoro-benzoylamino)-thiophen-2-yl]4-methyl-benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Methoxycarbonyl-2-methylphenylboronic acid | HCID 12163650 | — |
| Reactant | 2,6-Difluoro-N-[5-(3-trifluoromethyl-phenyl)-thiophen-2-yl]benzamide | HCID 58703377 | — |
| Product | 3-[5-(2,6-Difluoro-benzoylamino)-thiophen-2-yl]4-methyl-benzoic acid methyl ester | HCID 58703396 | — |
Reaction Steps
Compound 118 was synthesized in an analogous fashion as described for Compound 117 except that 5-methoxycarbonyl-2-methylbenzeneboronic acid was used instead of 3-trifluoromethylbenzeneboronic acid in the final step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08802721B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-b14776d471d640aebfe57fe6578f2b55 |
| Source note | uspto-grants-2014_08 |