2,6-Difluoro-N-[5-(3-trifluoromethyl-phenyl)-thiophen-2-yl]benzamide → 2,6-Difluoro-N-[5-(3-oxazol-5-yl-phenyl)-thiophen-2-yl]-benzamide

HRID 2404502Notes

Reaction equation

HRID 2404502 reaction equation
[F:1][C:2]1[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[C:3]=1[C:4]([NH:6][C:7]1[S:8][C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18](F)(F)F)[CH:13]=2)=[CH:10][CH:11]=1)=[O:5].[O:27]1C(C2C=C(B(O)O)C=CC=2)=[CH:30][N:29]=[CH:28]1>>[F:1][C:2]1[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[C:3]=1[C:4]([NH:6][C:7]1[S:8][C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]3[O:27][CH:28]=[N:29][CH:30]=3)[CH:13]=2)=[CH:10][CH:11]=1)=[O:5]

Participants

3

Reactant 2

HCID 587033772,6-Difluoro-N-[5-(3-trifluoromethyl-phenyl)-thiophen-2-yl]benzamideHCID 69380386[3-(1,3-Oxazol-5-yl)phenyl]boronic acid

Product 1

HCID 587033762,6-Difluoro-N-[5-(3-oxazol-5-yl-phenyl)-thiophen-2-yl]-benzamide

Procedure

Compound 121 was synthesized in an analogous fashion as described for Compound 117 except that 3-(oxazol-5-yl)-benzeneboronic acid was used instead of 3-trifluoromethylbenzeneboronic acid in the final step.

Sources & evidence

ORD record
ord-8d018db0b453465dbeeab49e72b9f35e
Source dataset
uspto-grants-2014_08
Patent number
US08802721B2

Reaction notes

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