Hydrochloric Acid → HCID 86680458, compound

HRID 240451Notes

Reaction equation

HRID 240451 reaction equation
[CH2:1]=[C:2]([C:4]1[N:5]=[CH:6][C:7]([O:10][C@H:11]2[CH2:26][N:14]3[CH2:15][CH2:16][N:17](C(OC(C)(C)C)=O)[CH2:18][C@@H:13]3[CH2:12]2)=[N:8][CH:9]=1)[CH3:3].[ClH:27]>O1CCOCC1>[ClH:27].[CH2:1]=[C:2]([C:4]1[N:5]=[CH:6][C:7]([O:10][C@H:11]2[CH2:26][N:14]3[CH2:15][CH2:16][NH:17][CH2:18][C@@H:13]3[CH2:12]2)=[N:8][CH:9]=1)[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86680457HCID 86680457, compound

Product 1

HCID 86680458HCID 86680458, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of the product from Example 202B (100 mg, 0.277 mmol) in 1,4-dioxane (1 mL) was added 4 N HCl in 1,4-dioxane (1 mL, 4.00 mmol). The resulting mixture was stirred at ambient temperature for 3 hours, and the mixture was then concentrated to give the title compound as an off-white solid (82 mg, quantitative).

Workup

  1. concentrationthe mixture was then concentrated

Sources & evidence

ORD record
ord-302ac28f85fd47b08fe301510e61e126
Source dataset
uspto-grants-2014_02
Patent number
US08648074B2

Reaction notes

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