HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (8aS)-7-(3-fluorobenzyl)hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-butyl (8aS)-7-(3-fluorobenzyl)-6-oxohexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate | HCID 86680467 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (8aS)-7-(3-fluorobenzyl)hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one hydrochloride | HCID 86680468 | — |
Reaction Steps
To a solution of the product from Example 213A (72 mg, 0.207 mmol) in 1,4-dioxane (1 mL) was added a 4 M solution of hydrogen chloride in 1,4-dioxane (1 mL, 4.0 mmol). The resulting mixture was stirred at room temperature for 90 minutes and concentrated and dried in vacuo to give the title compound (59 mg, quantitative).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08648074B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-7b0037ba3d0547a6810ccc0a6c7c0db7 |
| Source note | uspto-grants-2014_02 |