Hydrochloric Acid → (8aS)-7-(3-fluorobenzyl)hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one hydrochloride

HRID 240459Notes

Reaction equation

HRID 240459 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:23]=[CH:24][CH:25]=1)[CH2:5][CH:6]1[C:21](=[O:22])[N:9]2[CH2:10][CH2:11][N:12](C(OC(C)(C)C)=O)[CH2:13][C@@H:8]2[CH2:7]1.[ClH:26]>O1CCOCC1>[ClH:26].[F:1][C:2]1[CH:3]=[C:4]([CH:23]=[CH:24][CH:25]=1)[CH2:5][CH:6]1[C:21](=[O:22])[N:9]2[CH2:10][CH2:11][NH:12][CH2:13][C@@H:8]2[CH2:7]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86680467tert-butyl (8aS)-7-(3-fluorobenzyl)-6-oxohexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate

Product 1

HCID 86680468(8aS)-7-(3-fluorobenzyl)hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of the product from Example 213A (72 mg, 0.207 mmol) in 1,4-dioxane (1 mL) was added a 4 M solution of hydrogen chloride in 1,4-dioxane (1 mL, 4.0 mmol). The resulting mixture was stirred at room temperature for 90 minutes and concentrated and dried in vacuo to give the title compound (59 mg, quantitative).

Workup

  1. concentrationconcentrated
  2. customdried in vacuo

Sources & evidence

ORD record
ord-7b0037ba3d0547a6810ccc0a6c7c0db7
Source dataset
uspto-grants-2014_02
Patent number
US08648074B2

Reaction notes

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