4-Chlorophenol → HCID 57470220, compound

HRID 2404708Notes

Reaction equation

HRID 2404708 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[C:9](O)([CH3:12])([CH3:11])[CH3:10].CC#[N:16]>>[C:9]([C:6]1[CH:7]=[C:2]([Cl:1])[C:3]([NH2:16])=[CH:4][C:5]=1[OH:8])([CH3:12])([CH3:11])[CH3:10]

Participants

4

Reactant 3

HCID 46844-ChlorophenolHCID 6342AcetonitrileHCID 6386tert-Butanol

Product 1

HCID 57470220HCID 57470220, compound

Procedure

2-tert-Butyl-5-amino-4-chlorophenol (C-10) was synthesized following the general scheme above starting from 4-chlorophenol and tert-butanol. Overall yield (6%). HPLC ret. time 3.07 min, 10-99% CH3CN, 5 min run; ESI-MS 200.2 m/z (MH+).

Workup

  1. customOverall yield (6%)

Sources & evidence

ORD record
ord-7df5628fedb2476cb3a4b5dc79e988ce
Source dataset
uspto-grants-2014_08
Patent number
US08802700B2

Reaction notes

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