HRID240472

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：COc1ccc(Cl)cc1NC(=O)Nc1cccc2c1ccn2Cc1ccnc2c1ccn2C(=O)OC(C)(C)C

HCID68750472

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(Cl)cc1NC(=O)Nc1cccc2c1ccn2Cc1ccnc2[nH]ccc12.Cl

HCID68754864

未命名化合物

收率 180.3%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

1-(2-Methoxyl-5-chlorophenyl)-3-{1-[1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl]-1H-indol-4-yl}urea (500 mg, 0.92 mmol) was added to 25% HCl in methanol solution. The mixture was stirred overnight, then concentrated to afford the product 1-(2-Methoxyl-5-chlorophenyl)-3-[1-(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)-1H-indol-4-yl]urea hydrochloride (400 mg, 90%).

WORKUP

后处理

concentrationconcentrated