HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[(4-nitro-1H-indol-1-yl)methyl]-1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridine → 3-[(4-amino-1H-indol-1-yl)methyl]-1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[(4-nitro-1H-indol-1-yl)methyl]-1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridine | HCID 68748961 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-[(4-amino-1H-indol-1-yl)methyl]-1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridine | HCID 68752868 | 99.8% |
Reaction Steps
A round-bottom flask was charged with 3-[(4-nitro-1H-indol-1-yl)methyl]-1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridine (510 mg, 1.3 mmol), Pd/C (50 mg, 10%) and THF (30 mL). The mixture was then stirred under a hydrogen atmosphere for 2 h, filtered, and concentrated under reduced pressure to afford 3-[(4-amino-1H-indol-1-yl)methyl]-1-(t-butyloxycarbonyl)-1H-pyrrolo[2,3-b]pyridine (470 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08648086B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-e8f60f71e70045e5b43ef3bcc48e163b |
| Source note | uspto-grants-2014_02 |