Thymol → 5-Amino-2-isopropylphenol

HRID 2404850노트

반응식

HRID 2404850 반응식
[CH:1]([C:4]1[CH:9]=[CH:8][C:7](C)=[CH:6][C:5]=1[OH:11])([CH3:3])[CH3:2].C([O-])=O.[NH4+:15]>C(O)C.[Pd]>[NH2:15][C:7]1[CH:8]=[CH:9][C:4]([CH:1]([CH3:3])[CH3:2])=[C:5]([OH:11])[CH:6]=1

참가 물질

5

반응물 2

HCID 6989ThymolHCID 2723923Ammonium formate

생성물 1

HCID 598484345-Amino-2-isopropylphenol

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

To a refluxing solution of 2-isopropyl-5-methyl-phenol (1.3 g, 8.65 mmol) and ammonium formate (1.3 g, 20.62 mmol) in ethanol (50 mL) was added 10% Pd/C (887 mg, 8.33 mmol). The mixture was refluxed for an additional 5 minutes, cooled and filtered through a pad of celite. The solvent was removed by evaporation to give 5-amino-2-isopropylphenol which was used without further purification. 1H NMR (400 MHz, DMSO-d6) δ 8.70 (s, 1H), 6.71 (d, J=8.1 Hz, 1H), 6.04 (d, J=2.2 Hz, 1H), 5.97 (dd, J=8.1, 2.2 Hz, 1H), 4.65 (s, 2H), 3.08-2.94 (m, 1H), 1.07 (d, J=6.9 Hz, 6H).

후처리

  1. temperatureThe mixture was refluxed for an additional 5 minutes
  2. temperaturecooled
  3. filtrationfiltered through a pad of celite
  4. customThe solvent was removed by evaporation

출처 및 근거

ORD 기록
ord-7b472ea8a8794d13b4c291d1dc62e12c
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08802700B2

반응 노트

불러오는 중…