HCID 776593, compound → HCID 5201131, compound

HRID 2404945Notes

Reaction equation

HRID 2404945 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:7]2[CH2:20][CH2:19][CH2:18][CH2:17][C:8]=2[S:9][C:10]=1[NH:11][C:12]([CH:14]1[CH2:16][CH2:15]1)=[O:13])=[O:5])[CH3:2]>C1(C)C=CC=CC=1.O=[Mn]=O>[CH2:1]([O:3][C:4]([C:6]1[C:7]2[CH:20]=[CH:19][CH:18]=[CH:17][C:8]=2[S:9][C:10]=1[NH:11][C:12]([CH:14]1[CH2:16][CH2:15]1)=[O:13])=[O:5])[CH3:2]

Participants

4

Reactant 1

HCID 776593HCID 776593, compound

Product 1

HCID 5201131HCID 5201131, compoundYield 72%

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 1140TolueneSolvent

Conditions

Temperature
60 °C

Procedure

8.00 g MnO2 (Activated, Fluka) was added to the suspension of 10 millimol VI in 60 milliliter toluene, and the suspension was stirred at reflux temperature for 5 days. The reaction mixture cooled down to 60° C., filtrated, and evaporated to give the desired compound VII as solid crystal.

Workup

  1. temperatureat reflux temperature for 5 days
  2. filtrationfiltrated
  3. customevaporated

Sources & evidence

ORD record
ord-cfa5549887b64b29b839b07c9fcc9444
Source dataset
uspto-grants-2014_08
Patent number
US08802849B2

Reaction notes

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