Phosphoric Acid → HCID 86680545, compound

HRID 2404963Notes

Reaction equation

HRID 2404963 reaction equation
[CH3:1][C:2]([O:4][C:5]1[S:9][C:8]2[CH2:10][CH2:11][N:12]([CH:14]([C:22]([CH:24]3[CH2:26][CH2:25]3)=[O:23])[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:20]=3[F:21])[CH2:13][C:7]=2[CH:6]=1)=[O:3].[OH:27][P:28]([OH:31])([OH:30])=[O:29]>ClCCl>[CH3:1][C:2]([O:4][C:5]1[S:9][C:8]2[CH2:10][CH2:11][N:12]([CH:14]([C:22]([CH:24]3[CH2:26][CH2:25]3)=[O:23])[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:20]=3[F:21])[CH2:13][C:7]=2[CH:6]=1)=[O:3].[P:28]([O-:31])([O-:30])([O-:29])=[O:27]

Participants

4

Reactant 2

HCID 1004Phosphoric AcidHCID 6918456Prasugrel

Product 1

HCID 86680545HCID 86680545, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
9 °C

Procedure

To a solution of prasugrel base (0.252 g of) in 2.0 ml of dichloromethane at 0-5° C., a dropwise solution of 55.0 μL of 85% H3PO4 (aq) was added. An oily reaction mixture was obtained and stirred at 0-5° C. for about 7 hours and for an additional 17 hours at 8-10° C. The obtained crystals were filtered and dried at 40° C./vacuum for about 5 hours. Prasugrel phosphate form P2 was obtained (0.186 g).

Workup

  1. customAn oily reaction mixture was obtained
  2. filtrationThe obtained crystals were filtered
  3. customdried at 40° C./vacuum for about 5 hours
  4. customwas obtained (0.186 g)

Sources & evidence

ORD record
ord-17d08828f4374582af7d35900c0872aa
Source dataset
uspto-grants-2014_08
Patent number
US08802854B2

Reaction notes

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