Phosphoric Acid → HCID 86680545, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of prasugrel base (0.252 g of) in 2.0 ml of dichloromethane at 0-5° C., a dropwise solution of 55.0 μL of 85% H3PO4 (aq) was added. An oily reaction mixture was obtained and stirred at 0-5° C. for about 7 hours and for an additional 17 hours at 8-10° C. The obtained crystals were filtered and dried at 40° C./vacuum for about 5 hours. Prasugrel phosphate form P2 was obtained (0.186 g).

Provenance & Evidence