3,3,3-Triethoxyprop-1-yne → HCID 22570286, compound

HRID 24051Notes

Reaction equation

HRID 24051 reaction equation
Br[C:2]1[CH:3]=[N:4][CH:5]=[C:6]([O:8][CH2:9][C:10]([F:13])([F:12])[F:11])[CH:7]=1.[CH2:14]([O:16][C:17]([O:23][CH2:24][CH3:25])([O:20][CH2:21][CH3:22])[C:18]#[CH:19])[CH3:15]>>[CH2:24]([O:23][C:17]([O:16][CH2:14][CH3:15])([O:20][CH2:21][CH3:22])[C:18]#[C:19][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([O:8][CH2:9][C:10]([F:13])([F:12])[F:11])[CH:7]=1)[CH3:25]

Participants

3

Reactant 2

HCID 109209723,3,3-Triethoxyprop-1-yneHCID 225703523-Bromo-5-(2,2,2-trifluoroethoxy)pyridine

Product 1

HCID 22570286HCID 22570286, compoundYield 46%

Procedure

The title compound was synthesized from 3-bromo-5-(2,2,2-trifluoro-ethoxy)-pyridine and 3,3,3-triethoxypropyne using the procedure described in Example 43, step (e), in 46% yield. 1H NMR (CDCl3) δ 8.44 (bs, 1H), 8.35 (bs, 1H), 7.34 (m, 1H), 4.40 (q, 2H, J=7.9 Hz), 3.76 (q, 6H, J=7.1 Hz), 1.28 (t, 9H, J=7.1 Hz).

Sources & evidence

ORD record
ord-11e2f967ab0649b7be94a52068d1d18a
Source dataset
uspto-grants-2005_02
Patent number
US06855722B2

Reaction notes

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