Ethanol → 3-Bromo-5-ethoxypyridine

HRID 24052Notes

Reaction equation

HRID 24052 reaction equation
Br[C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Br:8])[CH:7]=1.[CH2:9]([OH:11])[CH3:10]>>[Br:8][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([O:11][CH2:9][CH3:10])[CH:7]=1

Participants

3

Reactant 2

HCID 702EthanolHCID 693693,5-Dibromopyridine

Product 1

HCID 122934803-Bromo-5-ethoxypyridineYield 60%

Procedure

The title compound was synthesized from 3,5-dibromopyridine and ethanol using the procedure described in Example 53, step (a) in 60% yield. 1H NMR (CDCl3) δ 8.27 (bs, 1H), 8.23 (bs, 1H), 7.33 (m, 1H), 4.06 (q, 2H, J=7.0 Hz), 1.43 (t, 3H, J=7.0 Hz).

Sources & evidence

ORD record
ord-4c55b4c1142947ad8cbcf5785fb97f8f
Source dataset
uspto-grants-2005_02
Patent number
US06855722B2

Reaction notes

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