反应详情

温度

60 °C

The compound of example 15 (195 mg, 0.397 mmol) was dissolved in dioxane (2 ml), lithium hydroxide (1.99 ml of an aqueous 1 M solution, 1.99 mmol) was added, and the mixture was stirred at 60° C. for 1 h. The mixture was partitioned between 2 N hydrochloric acid and EA, the aqueous phase extracted with EA, and the combined organic extracts were dried over sodium sulfate, filtered and evaporated to dryness to give 180 mg of the title compound.

1. customThe mixture was partitioned between 2 N hydrochloric acid and EA
2. extractionthe aqueous phase extracted with EA
3. dry with materialthe combined organic extracts were dried over sodium sulfate
4. filtrationfiltered
5. customevaporated to dryness