反应详情

温度

110 °C

The product from Example 42A (60 mg, 0.14 mmol) and Lawesson's reagent (27 mg, 0.068 mmol) were combined with toluene (3 mL) and stirred at 110° C. for 18 h. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure and purified by silica gel flash chromatography (EtOAc, Rf=0.35) to provide the title compound (60 mg, 97%). MS (APCI) m/z 387 (M+H)+.

1. temperatureAfter cooling to room temperature
2. concentrationthe reaction mixture was concentrated under reduced pressure
3. custompurified by silica gel flash chromatography (EtOAc, Rf=0.35)