反应详情

温度

100 °C

A mixture of 2-amino-5-nitrobenzonitrile (30.0 g, 184 mmol) and dimethoxy-N,N-dimethylmethanamine (29.6 mL, 223 mmol) was heated to 100° C. for 2 hours. The reaction mixture was concentrated under reduced pressure and dissolved in dichloromethane. The solution was run through a silica plug washing the plug with ethyl acetate. The filtrate was concentrated under reduced pressure, stirred with ether and filtered to provide the product (35.0 g, 87%) as yellow solid.

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. dissolutiondissolved in dichloromethane
3. washwashing the plug with ethyl acetate
4. concentrationThe filtrate was concentrated under reduced pressure
5. filtrationfiltered