Hydrazine → 4-(Benzyloxy)-2-hydrazinylpyridine

HRID 240546Notes

Reaction equation

HRID 240546 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11](Cl)[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:16][NH2:17]>N1C=CC=CC=1>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]([NH:16][NH2:17])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 534041974-(Benzyloxy)-2-chloropyridine

Product 1

HCID 669373074-(Benzyloxy)-2-hydrazinylpyridine

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution of 4-(benzyloxy)-2-chloropyridine (4.89 g, 22.30 mmol) in pyridine (120 mL) was added hydrazine (45 mL, 22.30 mmol). After heating to reflux for 18 hours, the mixture was concentrated to provide the crude product, which was used without further purification.

Workup

  1. temperatureAfter heating
  2. temperatureto reflux for 18 hours
  3. concentrationthe mixture was concentrated

Sources & evidence

ORD record
ord-f6aa91d15140450d90740aa5fd3c2336
Source dataset
uspto-grants-2014_02
Patent number
US08648087B2

Reaction notes

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