7-(Benzyloxy)-[1,2,4]triazolo[4,3-a]pyridine → HCID 178516347, compound

HRID 240548Notes

Reaction equation

HRID 240548 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][N:12]2[CH:15]=[N:16][N:17]=[C:11]2[CH:10]=1)C1C=CC=CC=1>C(O)C.[Pd]>[N:17]1[N:16]=[CH:15][N:12]2[CH:13]=[CH:14][C:9]([OH:8])=[CH:10][C:11]=12

Participants

4

Reactant 1

HCID 669370477-(Benzyloxy)-[1,2,4]triazolo[4,3-a]pyridine

Product 1

HCID 178516347HCID 178516347, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of 7-(benzyloxy)-[1,2,4]triazolo[4,3-a]pyridine (0.512 g, 2.27 mmol) in ethanol (30 mL) was added Pd/C (0.5 g). After stirring under a hydrogen balloon for 3 hours, the mixture was filtered through celite and washed with ethanol (30 mL). The filtrate was concentrated under reduced pressure and chromatographed (20:1 dichloromethane/methanol) to provide the product.

Workup

  1. filtrationthe mixture was filtered through celite
  2. washwashed with ethanol (30 mL)
  3. concentrationThe filtrate was concentrated under reduced pressure
  4. customchromatographed (20:1 dichloromethane/methanol)
  5. customto provide the product

Sources & evidence

ORD record
ord-9687788a58914adfa5a8c4bbea2dd39b
Source dataset
uspto-grants-2014_02
Patent number
US08648087B2

Reaction notes

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