Tert-butyl 4-(benzyloxy)pyridin-2-ylcarbamate → HCID 178452896, compound

HRID 240551Notes

Reaction equation

HRID 240551 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]([NH:15][C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19])[CH:10]=1)C1C=CC=CC=1>CO.[Pd]>[OH:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]([NH:15][C:16](=[O:22])[O:17][C:18]([CH3:20])([CH3:19])[CH3:21])[CH:10]=1

Participants

4

Reactant 1

HCID 66937350Tert-butyl 4-(benzyloxy)pyridin-2-ylcarbamate

Product 1

HCID 178452896HCID 178452896, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of tert-butyl 4-(benzyloxy)pyridin-2-ylcarbamate (5.89 g, 19.6 mmol) in methanol was added palladium on carbon (1.04 g, 0.981 mmol). After stirring under a hydrogen balloon at room temperature for 70 minutes, the solids were removed by filtration. The filtrate was concentrated under reduced pressure and solidified under high vacuum to provide the product (4.12 g, 99%) as white solid.

Workup

  1. customthe solids were removed by filtration
  2. concentrationThe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-f8e0b6e7abb3461aa7b5e1fed25787b0
Source dataset
uspto-grants-2014_02
Patent number
US08648087B2

Reaction notes

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