1,1'-Carbonyldiimidazole → HCID 66673986, compound

HRID 2405601Notes

Reaction equation

HRID 2405601 reaction equation
[F:1][C:2]1[C:7]([F:8])=[C:6]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:11]=2[I:17])[C:5]([NH2:18])=[C:4]([O:19][CH3:20])[CH:3]=1.[C:21](N1C=CN=C1)(N1C=CN=C1)=[O:22]>C(Cl)Cl>[F:1][C:2]1[CH:3]=[C:4]([O:19][CH3:20])[C:5]2[NH:18][C:21](=[O:22])[N:9]([C:10]3[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:11]=3[I:17])[C:6]=2[C:7]=1[F:8]

Participants

4

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 86618900HCID 86618900, compound

Product 1

HCID 66673986HCID 66673986, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To the stirred solution of 5,6-difluoro-N1-(4-fluoro-2-iodophenyl)-3-methoxybenzene-1,2-diamine (0.17 gm, 0.43 mmol) in CH2Cl2 (2 ml), 1,1′-Carbonyldiimidazole (0.085 gm, 0.53 mmol) was added. This reaction mixture was kept stifling at room temperature for 16 hours when product precipitated out. The white solid was filtered and used further without any purification. (0.089 gm); m/z=419 [M−1]−.

Workup

  1. customwhen product precipitated out
  2. filtrationThe white solid was filtered
  3. customused further without any purification

Sources & evidence

ORD record
ord-6b8200176cae48c19fded68a20dbf89c
Source dataset
uspto-grants-2014_08
Patent number
US08808742B2

Reaction notes

Loading…