Triethylamine → 2-Propenoic acid, 2,5-dioxo-1-pyrrolidinyl ester

Temperature

0 °C

To a solution of N-hydroxysuccinimide (NAS) (1.15 g, 10.0 mmol) and triethylamine (1.53 ml) in chloroform (15 ml), acryloyl chloride (0.99 g, 11.0 mmol), cooled at 0° C., was added dropwise, under mechanical stirring, over a period of 30-min. After an additional stirring of 20 min at 0° C., the solution was washed with ice-cold water (8 ml for 2 times), dried on Na2SO4 and then filtered. 2,5-Di-tert-butylhydroquinone (0.5 mg) (polymerization inhibitor) was added to the chloroform solution, which was concentrated to a volume of 3 ml, using a rotary evaporator and filtered. Ethyl acetate (3 ml) and n-hexane (2 ml) were slowly added while stirring to the chloroform solution, which was left at 0° C. for several hours. The precipitate, a colorless solid, was separated by filtration and washed with an ice-cold solution of ethyl acetate/n-hexane (4/1) and then washed only with n-hexane.

1. additionwas added dropwise, under mechanical stirring, over a period of 30-min
2. washthe solution was washed with ice-cold water (8 ml for 2 times)
3. customdried on Na2SO4
4. filtrationfiltered
5. addition2,5-Di-tert-butylhydroquinone (0.5 mg) (polymerization inhibitor) was added to the chloroform solution, which
6. concentrationwas concentrated to a volume of 3 ml
7. customa rotary evaporator
8. filtrationfiltered
9. additionEthyl acetate (3 ml) and n-hexane (2 ml) were slowly added
10. stirringwhile stirring to the chloroform solution, which
11. waitwas left at 0° C. for several hours
12. customThe precipitate, a colorless solid, was separated by filtration
13. washwashed with an ice-cold solution of ethyl acetate/n-hexane (4/1)
14. washwashed only with n-hexane

ORD record

ord-d120abaec18d47f78676d39163e45e79

Source dataset

uspto-grants-2014_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08809071B2