Water → HCID 86675565, compound

Temperature

-15 °C

3-allyl-6-methylheptenone (20.0 g, 120 mmol) was dissolved in anhydrous THF (100 ml) and the solution cooled to −15° C. under stirring. A 3.5M solution of LiAlH4 (in THF/toluene, 12.0 ml, 42 mmol, 0.35 mol. eq.) was added dropwise under argon over 30 min. The reaction mixture was then stirred at −15° C. for 1 hour. The temperature was raised to 0° C., and the mixture carefully hydrolyzed by successive dropwise additions of water (1.60 g), 15% aqueous NaOH (1.60 g) and water (4.80 g), while keeping the reaction mixture at 0° C. The mixture was allowed to warm to room temperature, and the precipitate filtered. Evaporation of the solvent afforded the crude product. Fractional distillation though a 10 cm Vigreux column afforded the desired compound (16.94 g (83% yield).

1. stirringThe reaction mixture was then stirred at −15° C. for 1 hour
2. temperatureThe temperature was raised to 0° C.
3. customat 0° C
4. temperatureto warm to room temperature
5. filtrationthe precipitate filtered
6. customEvaporation of the solvent
7. customafforded the crude product
8. distillationFractional distillation though a 10 cm Vigreux column

ORD record

ord-5e2129c29ac44712a7d4a2bb6e134dad

Source dataset

uspto-grants-2014_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08809256B2