Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | HCID 178518067 | HCID 178518067 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 178518066 | HCID 178518066 | — |
Reaction Steps
To a solution of thieno[2,3-d]pyrimidin-4-ol (3.0 g, 20 mmol) in glacial acetic acid (40 mL) was added bromine (6.3 g, 39 mmol). After heating to 80° C. for 1.5 hours, the reaction mixture was cooled to room temperature and poured into saturated NaHCO3 and ice. The solid was filtered, washed with water and dried to provide the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08648087B2 |
|---|
| Source dataset | uspto-grants-2014_02 |
|---|
| ORD ID | ord-5c86d25a107c4353b64bd1e5448c939f |
|---|
| Source note | uspto-grants-2014_02 |
|---|
