Bromine → HCID 178518066, compound

HRID 240569Notes

Reaction equation

HRID 240569 reaction equation
[N:1]1[C:6]2[S:7][CH:8]=[CH:9][C:5]=2[C:4]([OH:10])=[N:3][CH:2]=1.[Br:11]Br.C([O-])(O)=O.[Na+]>C(O)(=O)C>[Br:11][C:8]1[S:7][C:6]2[N:1]=[CH:2][N:3]=[C:4]([OH:10])[C:5]=2[CH:9]=1

Participants

5

Reactant 3

HCID 24408BromineHCID 516892Sodium BicarbonateHCID 178518067HCID 178518067, compound

Product 1

HCID 178518066HCID 178518066, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of thieno[2,3-d]pyrimidin-4-ol (3.0 g, 20 mmol) in glacial acetic acid (40 mL) was added bromine (6.3 g, 39 mmol). After heating to 80° C. for 1.5 hours, the reaction mixture was cooled to room temperature and poured into saturated NaHCO3 and ice. The solid was filtered, washed with water and dried to provide the product.

Workup

  1. temperaturethe reaction mixture was cooled to room temperature
  2. filtrationThe solid was filtered
  3. washwashed with water
  4. customdried
  5. customto provide the product

Sources & evidence

ORD record
ord-5c86d25a107c4353b64bd1e5448c939f
Source dataset
uspto-grants-2014_02
Patent number
US08648087B2

Reaction notes

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