Tetramethyl orthocarbonate → HCID 68357450, compound

HRID 2405692Notes

Reaction equation

HRID 2405692 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([S:13]([NH2:16])(=[O:15])=[O:14])[C:9]([OH:12])([CH3:11])[CH3:10])=[CH:4][CH:3]=1.[CH3:17][O:18][C:19](OC)(OC)OC>C(O)(=O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[C:9]([CH3:11])([CH3:10])[O:12][C:17]([O:18][CH3:19])=[N:16][S:13]2(=[O:14])=[O:15])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 74613Tetramethyl orthocarbonateHCID 68293493HCID 68293493, compound

Product 1

HCID 68357450HCID 68357450, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 500 mg of 1-(4-bromophenyl)-2-hydroxy-2-methylpropane-1-sulfonamide in 2 ml of tetramethoxymethane and 0.5 ml of acetic acid was stirred at 100° C. for 3 hours. After the removal of the solvent under reduced pressure, the residue (565 mg) was used in the next reaction without further purification.

Workup

  1. customAfter the removal of the solvent under reduced pressure
  2. customthe residue (565 mg) was used in the next reaction without further purification

Sources & evidence

ORD record
ord-c11f589f13e14fafb1b36cb49e84c594
Source dataset
uspto-grants-2014_08
Patent number
US08809324B2

Reaction notes

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