Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formamide | HCID 713 | — |
| Reactant | Benzoic acid, 2-amino-5-iodo- | HCID 72911 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 178518013 | HCID 178518013 | 83% |
Reaction Steps
A mixture of 2-amino-5-iodobenzoic acid (125 g, 475 mmol) and formamide (200 mL) was heated to 190° C. for 2 hours. After cooling to room temperature, the reaction mixture was poured into water (500 mL) and stirred for 2 hours. The solids were filtered and dried under high vacuum to provide the product (108 g, 83%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08648087B2 |
|---|
| Source dataset | uspto-grants-2014_02 |
|---|
| ORD ID | ord-1cf203d6a8f34d2ea4d9ba40e1884b22 |
|---|
| Source note | uspto-grants-2014_02 |
|---|
