反应详情

温度

65 °C

To a solution of 2-aminobenzene-1,4-diol (2.40 g, 19.2 mmol) in triethylorthoformate (10 mL) was added 3 drops of concentrated HCl. After heating to 65° C. for 30 minutes and stirring at room temperature for 16 hours, the mixture was poured into water and extracted with ethyl acetate (2×). The organic phase was washed with HCl (2N) and saturated NaHCO3, dried, and concentrated under reduced pressure to provide the product (2.09 g, 81%) as red-black solid.

1. extractionextracted with ethyl acetate (2×)
2. washThe organic phase was washed with HCl (2N) and saturated NaHCO3
3. customdried
4. concentrationconcentrated under reduced pressure