Sodium Hydroxide → HCID 59756561, compound

HRID 2405752Notes

Reaction equation

HRID 2405752 reaction equation
P(Cl)(Cl)([Cl:3])=O.[NH2:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][C:16]=1[Cl:17])[C:13](=O)[NH:12][CH:11]=[CH:10]2.[OH-].[Na+]>>[Cl:3][C:13]1[C:14]2[C:9](=[CH:8][C:7]([NH2:6])=[C:16]([Cl:17])[CH:15]=2)[CH:10]=[CH:11][N:12]=1

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 24813Phosphorus oxychlorideHCID 108780456-amino-7-chloro-2H-isoquinolin-1-one

Product 1

HCID 59756561HCID 59756561, compoundYield 55%

Conditions

Temperature
100 °C

Procedure

To 20.0 mL (215 mmol) of phosphorous oxychloride, cooled to 0 C, was added 5.00 g (25.7 mmol) of 6-amino-7-chloro-2H-isoquinolin-1-one in portions. The mixture was heated to 100° C. for 3 h then cooled to room temperature and poured over ice. After all of the ice had melted the pH of the mixture was adjusted to slightly alkaline by the slow addition of a 10% aqueous NaOH solution. A yellow solid precipitated from solution and was collected by filtration, washed with water and dried over anhydrous Na2SO4 to provide 3.0 g (55%) of 1,7-dichloro-isoquinolin-6-ylamine. MS calc. for C9H7Cl2N2 [M+H]+: 214.08. Found: 213.23 and 215.23.

Workup

  1. temperaturethen cooled to room temperature
  2. additionpoured over ice
  3. customA yellow solid precipitated from solution
  4. filtrationwas collected by filtration
  5. washwashed with water
  6. dry with materialdried over anhydrous Na2SO4

Sources & evidence

ORD record
ord-7e9deb1825fc46aa984d99e17f66c362
Source dataset
uspto-grants-2014_08
Patent number
US08809326B2

Reaction notes

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