2-Amino-2-cyclopropylacetic acid → HCID 68616869, compound

HRID 2405804Notes

Reaction equation

HRID 2405804 reaction equation
C[C:2]([CH3:17])([CH3:16])[CH:3]([NH:7][C:8]([O:10][CH:11]1[CH2:15][CH2:14][O:13][CH2:12]1)=[O:9])[C:4]([OH:6])=[O:5].NC(C1CC1)C(O)=O.O1CCC(OC(=O)OC2C=CC([N+]([O-])=O)=CC=2)C1>>[CH:2]1([CH:3]([NH:7][C:8]([O:10][CH:11]2[CH2:15][CH2:14][O:13][CH2:12]2)=[O:9])[C:4]([OH:6])=[O:5])[CH2:16][CH2:17]1

Participants

4

Reactant 3

HCID 41122502-Amino-2-cyclopropylacetic acidHCID 15343685HCID 15343685, compoundHCID 66749849HCID 66749849, compound

Product 1

HCID 68616869HCID 68616869, compound

Procedure

Cyclopropyl-[(tetrahydro-furan-3-yloxycarbonylamino)]-acetic acid was prepared according to the method presented in the synthesis of the intermediate 3,3-dimethyl-2-(tetrahydro-furan-3-yloxycarbonylamino)-butyric acid in Example 62. Treatment of amino-cyclopropyl-acetic acid with carbonic acid 4-nitro-phenyl ester tetrahydro-furan-3-yl ester occurred under the same conditions, adjusted for scale, to provide the desired cyclopropyl-[(tetrahydro-furan-3-yloxycarbonylamino)]-acetic acid.

Workup

  1. customCyclopropyl-[(tetrahydro-furan-3-yloxycarbonylamino)]-acetic acid was prepared

Sources & evidence

ORD record
ord-72af620641d443beb3ee29214e538269
Source dataset
uspto-grants-2014_08
Patent number
US08809267B2

Reaction notes

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