反应详情

Amoniumformiate (1.0 g) was added into a suspension of (R)-tert-butyl 3-(5-fluoro-2-nitrophenoxy)piperidine-1-carboxylate and palladium on charcoal (125.0 mg) in anhydrous MeOH (10.0 ml) at room temperature. The reaction was stirred at room temperature overnight when LCMS analysis indicated consumption of the starting material. The solution was filtered through celite and washed with MeOH. The filtrate was concentrated in vacuo. The residue was triturated with diethylether to remove the ammoniumformiate residues. The solution was filtered and concentrated in vacuo. The residue was purified by chromatography.

1. customconsumption of the starting material
2. filtrationThe solution was filtered through celite
3. washwashed with MeOH
4. concentrationThe filtrate was concentrated in vacuo
5. customThe residue was triturated with diethylether
6. customto remove the ammoniumformiate residues
7. filtrationThe solution was filtered
8. concentrationconcentrated in vacuo
9. customThe residue was purified by chromatography