Hydrochloric Acid → HCID 67418756, compound

HRID 2406031Notes

Reaction equation

HRID 2406031 reaction equation
C(OC(=O)[NH:7][C:8]([CH2:32][OH:33])([CH2:30][OH:31])[CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[C:13]([C:26]([F:29])([F:28])[F:27])[CH:12]=1)(C)(C)C.O1CCOCC1.[ClH:41]>C(Cl)Cl>[ClH:41].[NH2:7][C:8]([CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[C:13]([C:26]([F:27])([F:28])[F:29])[CH:12]=1)([CH2:30][OH:31])[CH2:32][OH:33]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 57704527HCID 57704527, compound

Product 1

HCID 67418756HCID 67418756, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Compound 9-7 (490 mg) was dissolved in methylene chloride (5 ml), dioxane containing hydrogen chloride (4 mol/l, 5 ml) was added, and the mixture was stirred at room temperature for 12 hr. The reaction mixture was concentrated, and the residue was washed with diethyl ether to give the object product (350 mg) as a white powder.

Workup

  1. additionwas added
  2. concentrationThe reaction mixture was concentrated
  3. washthe residue was washed with diethyl ether

Sources & evidence

ORD record
ord-bba1b4bb174e4961ad2d617a21a963f1
Source dataset
uspto-grants-2014_08
Patent number
US08809304B2

Reaction notes

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