Hydrochloric Acid → HCID 67417413, compound
Reaction equation
C(OC(=O)[NH:7][C:8]1([CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])=[C:20]([C:31]([F:34])([F:33])[F:32])[CH:19]=2)[CH2:13][O:12]C(C)(C)[O:10][CH2:9]1)(C)(C)C.[ClH:36]>C(O)C>[ClH:36].[NH2:7][C:8]([CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])=[C:20]([C:31]([F:32])([F:33])[F:34])[CH:19]=1)([CH2:9][OH:10])[CH2:13][OH:12]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 80 °C
Procedure
Compound 11-1 (620 mg) was dissolved in ethanol (15 ml), concentrated hydrochloric acid (2.5 ml) was added, and the mixture was stirred at 80° C. for 3 hr. The reaction mixture was concentrated, and the residue was washed with diethyl ether to give the object product (465 mg) as a white powder.
Workup
- concentrationThe reaction mixture was concentrated
- washthe residue was washed with diethyl ether
Sources & evidence
- ORD record
- ord-0290a0f1652c4b43822f1b72d116c789
- Source dataset
- uspto-grants-2014_08
- Patent number
- US08809304B2
Reaction notes
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